ADVICE AND HELP FOR FRIENDS AND FAMILY OF PEOPLE WITH CHRONIC HEART FAILURE

• Increased risk of irregular or rapid heartbeat (atrial fibrillation or heart rhythm problems). Tell your doctor if you have symptoms of an irregular or rapid heartbeat, such as feeling that your heart is pounding or racing (palpitations), chest pressure, worsened shortness of breath, near fainting or fainting.
• Low heart rate (bradycardia). Tell your doctor if you have a slowing of your heart rate or if you have symptoms of a low heart rate such as dizziness, fatigue, lack of energy, or have low blood pressure. Low heart rate is a common side effect of Corlanor^® and can be serious.

• You have symptoms of heart failure that recently worsened
• You have low blood pressure (less than 90/50 mm Hg)
• You have a certain heart condition called sick sinus syndrome, sinoatrial block, or 3rd-degree atrioventricular block
• You have a slow resting heart rate (less than 60 beats per minute) before treatment with Corlanor^®
• You are allergic to ivabradine or any of the ingredients in Corlanor^®. See end of the Medication Guide for a complete list of ingredients in Corlanor^®
• You are taking medicines that can change how much Corlanor^® gets into your body after it is swallowed. Your doctor can advise you if you are taking a medicine that should not be used with Corlanor^®

What should I tell my doctor before taking Corlanor^®?

Before you take Corlanor^®, tell your doctor about all of your medical conditions, including if you:

• Have any other heart problems, including heart rhythm problems, a slow heart rate, or a heart conduction problem
• Are breastfeeding or plan to breastfeed. It is not known if Corlanor^® passes into your breast milk. You and your doctor should decide if you will take Corlanor^® or breastfeed. You should not do both.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Corlanor^® may affect the way other medicines work, and other medicines may affect how Corlanor^® works, and could cause serious side effects.

What are the possible side effects of Corlanor^®?

The most common side effects of Corlanor^® are:

• Increased blood pressure
• Temporary brightness in your field of vision, usually caused by sudden changes in light (luminous phenomena). This brightness usually happens within the first 2 months of treatment with Corlanor^® and usually goes away during or after treatment with Corlanor^®. Use caution when driving or operating machinery where sudden changes in light can happen, especially when driving at night.

These are not all the side effects of Corlanor^®. Ask your doctor or pharmacist for more information. You may report side effects to FDA at 1-800-FDA-1088.

Please see Full Prescribing Information and Medication Guide.

Indication

Corlanor^® is a prescription medicine that is used to reduce the risk of hospitalization due to worsening heart failure. Corlanor^® is used in certain people who have persistent (chronic) heart failure caused by the lower-left part of their heart not contracting well. Corlanor^® is used to treat patients who have symptoms of heart failure that are stable, a normal heartbeat with a resting heart rate of at least 70 beats per minute and are also taking beta-blockers at the highest dose they can tolerate. Corlanor^® can also be used when there is a reason that patients cannot take beta-blockers.